Advances in Enzymology and Related Areas of Molecular - download pdf or read online
By Alton Meister
Advances in Enzymology and similar parts of Molecular Biology is a seminal sequence within the box of biochemistry, supplying researchers entry to authoritative experiences of the newest discoveries in all components of enzymology and molecular biology. those landmark volumes date again to 1941, supplying an unequalled view of the ancient improvement of enzymology. The sequence bargains researchers the newest figuring out of enzymes, their mechanisms, reactions and evolution, roles in complicated organic technique, and their program in either the laboratory and undefined. every one quantity within the sequence beneficial properties contributions by way of prime pioneers and investigators within the box from world wide. All articles are rigorously edited to make sure thoroughness, caliber, and clarity.
With its wide selection of subject matters and lengthy ancient pedigree, Advances in Enzymology and similar components of Molecular Biology can be utilized not just by means of scholars and researchers in molecular biology, biochemistry, and enzymology, but in addition via any scientist attracted to the invention of an enzyme, its homes, and its applications.
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Extra info for Advances in Enzymology and Related Areas of Molecular Biology, Volume 53
Biltonen, R. , 36, 2112 (1977). 156. Biophys. Acta, 505, 95 (1978). 157. , Erickson, H. , Proc. Natl. Acad. Sci. , 74, 5372 (1977). 158. Karr, T. , Podrasky, A. , and Purich, D. , Proc. Natl. Acad. Sci. , 76, 5475 (1979). 159. Lefkowitz, R. , and Stadel, J. , Current Topics in Cellular Regulation, 17, 205 (1980). Advances in Enzymology and Related Areas of Molecular Biology, Volume 53 Edited by Alton Meister Copyright © 1982 by John Wiley & Sons, Inc. 6-B I S PH 0 S PH A T A S E By STEPHEN J. BENKOVIC and MARGARET M.
In the case of the hydrolyzable form GTP, the GDP liganded nucleotide regulatory protein cannot further activate the catalytic unit. Figure 5 presents an overall model that attempts to incorporate the various interactions discussed in detail earlier. Several points are deserving of emphasis. It should be noted that substjtution of GDP by GTP on the nucleotide regulatory protein normally involves the interaction of the hormone-bound receptor with the nucleotide regulatory protein. Evidence for this interaction has been provided by the direct study of the molecular size of solubilized agonist prelabeled receptor (1 32) and also by computer modeling of agonist-specific binding of receptor systems (127,131).
Pinkus, K. V. Thimann, and E. B. , Academic Press, New York, 1964, 6. , Pohl, S. , Krans, M. , Adv. in Biochem. , 3, 185 (1970). 7. Levey, G. , Ann. N. Acad. , 185, 449 (197 1). 8. , Pohl, S . , and Krans, M. , J. Biol. , 246, 1877 (1971). 9. , Krans, M. , Pohl, S. , J. Biol. , 246, 1872 (1971). 10. Lefkowitz, R. , Proc. Natl. Acad. S. 65, 745 (1970). 11. Lefkowitz, R. , Caron, M. , and Williams, L. , Membrane Bound Hormone Receptors in Membrane Bound Enzymes, A. , Plenum Press, New York, 1975.
Advances in Enzymology and Related Areas of Molecular Biology, Volume 53 by Alton Meister